5MYB

Homodimerization of Tie2 Fibronectin-like domains 2 and 3 in space group P21

Summary for 5MYB

Entry DOI	10.2210/pdb5myb/pdb
Descriptor	Angiopoietin-1 receptor, beta-D-mannopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
Functional Keywords	receptor, fibronectin-like domains, dimerization, homotypic interactions, signaling protein
Biological source	Homo sapiens (Human)
Cellular location	Cell membrane; Single-pass type I membrane protein: Q02763
Total number of polymer chains	2
Total formula weight	77062.40
Authors	Leppanen, V.-M.,Saharinen, P.,Alitalo, K. (deposition date: 2017-01-26, release date: 2017-04-26, Last modification date: 2024-05-01)
Primary citation	Leppanen, V.M.,Saharinen, P.,Alitalo, K. Structural basis of Tie2 activation and Tie2/Tie1 heterodimerization. Proc. Natl. Acad. Sci. U.S.A., 114:4376-4381, 2017 Cited by PubMed: 28396439 DOI: 10.1073/pnas.1616166114 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation