5MXX

Crystal structure of human SR protein kinase 1 (SRPK1) in complex with compound 1

Summary for 5MXX

Entry DOI	10.2210/pdb5mxx/pdb
Descriptor	SRPK1, 5-methyl-~{N}-[2-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)phenyl]furan-2-carboxamide, 1,2-ETHANEDIOL, ... (6 entities in total)
Functional Keywords	splicing, phosphorylation, structural genomics, structural genomics consortium, sgc
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	46826.45
Authors	Tallant, C.,Redondo, C.,Batson, J.,Toop, H.D.,Babaebi-Jadidib, R.,Savitsky, P.,Elkins, J.M.,Newman, J.A.,Burgess-Brown, N.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bates, D.O.,Morris, J.C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2017-01-25, release date: 2017-05-24, Last modification date: 2024-01-17)
Primary citation	Batson, J.,Toop, H.D.,Redondo, C.,Babaei-Jadidi, R.,Chaikuad, A.,Wearmouth, S.F.,Gibbons, B.,Allen, C.,Tallant, C.,Zhang, J.,Du, C.,Hancox, J.C.,Hawtrey, T.,Da Rocha, J.,Griffith, R.,Knapp, S.,Bates, D.O.,Morris, J.C. Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease. ACS Chem. Biol., 12:825-832, 2017 Cited by PubMed: 28135068 DOI: 10.1021/acschembio.6b01048 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.75 Å)

Structure validation