5MXX

Crystal structure of human SR protein kinase 1 (SRPK1) in complex with compound 1

5MXX の概要

• エントリーDOI: 10.2210/pdb5mxx/pdb
• 分子名称: SRPK1, 5-methyl-~{N}-[2-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)phenyl]furan-2-carboxamide, 1,2-ETHANEDIOL, ... (6 entities in total)
• 機能のキーワード: splicing, phosphorylation, structural genomics, structural genomics consortium, sgc
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 46826.45

構造登録者

Tallant, C.,Redondo, C.,Batson, J.,Toop, H.D.,Babaebi-Jadidib, R.,Savitsky, P.,Elkins, J.M.,Newman, J.A.,Burgess-Brown, N.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bates, D.O.,Morris, J.C.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2017-01-25, 公開日: 2017-05-24, 最終更新日: 2024-01-17)

• 主引用文献: Batson, J.,Toop, H.D.,Redondo, C.,Babaei-Jadidi, R.,Chaikuad, A.,Wearmouth, S.F.,Gibbons, B.,Allen, C.,Tallant, C.,Zhang, J.,Du, C.,Hancox, J.C.,Hawtrey, T.,Da Rocha, J.,Griffith, R.,Knapp, S.,Bates, D.O.,Morris, J.C.; Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease.; ACS Chem. Biol., 12:825-832, 2017; PubMed: 28135068; DOI: 10.1021/acschembio.6b01048

実験手法

X-RAY DIFFRACTION (1.75 Å)