5MXR

Crystal Structure of the Acquired VIM-2 Metallo-beta-Lactamase in Complex with ANT-330 Inhibitor

5MXR の概要

• エントリーDOI: 10.2210/pdb5mxr/pdb
• 分子名称: Beta-lactamase VIM-2, ZINC ION, ACETATE ION, ... (5 entities in total)
• 機能のキーワード: metallo-beta-lactamase fold, zinc-dependent hydrolase, pfam00753, alpha-beta-beta-alpha sandwich, hydrolase
• 由来する生物種: Pseudomonas aeruginosa
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 25590.41

構造登録者

Docquier, J.D.,De Luca, F.,Benvenuti, M.,Di Pisa, F.,Pozzi, C.,Mangani, S. (登録日: 2017-01-24, 公開日: 2018-03-14, 最終更新日: 2024-05-08)

• 主引用文献: Leiris, S.,Coelho, A.,Castandet, J.,Bayet, M.,Lozano, C.,Bougnon, J.,Bousquet, J.,Everett, M.,Lemonnier, M.,Sprynski, N.,Zalacain, M.,Pallin, T.D.,Cramp, M.C.,Jennings, N.,Raphy, G.,Jones, M.W.,Pattipati, R.,Shankar, B.,Sivasubrahmanyam, R.,Soodhagani, A.K.,Juventhala, R.R.,Pottabathini, N.,Pothukanuri, S.,Benvenuti, M.,Pozzi, C.,Mangani, S.,De Luca, F.,Cerboni, G.,Docquier, J.D.,Davies, D.T.; SAR Studies Leading to the Identification of a Novel Series of Metallo-beta-lactamase Inhibitors for the Treatment of Carbapenem-Resistant Enterobacteriaceae Infections That Display Efficacy in an Animal Infection Model.; Acs Infect Dis., 5:131-140, 2019; PubMed: 30427656; DOI: 10.1021/acsinfecdis.8b00246

実験手法

X-RAY DIFFRACTION (1.75 Å)