5MWJ
Structure Enabled Discovery of a Stapled Peptide Inhibitor to Target the Oncogenic Transcriptional Repressor TLE1
Summary for 5MWJ
Entry DOI | 10.2210/pdb5mwj/pdb |
Descriptor | Transducin-like enhancer protein 1, DIMETHYL SULFOXIDE, pepide inhibtor, ... (4 entities in total) |
Functional Keywords | transducin-like; constrained peptide inhibitor; transcriptional corepressor, transcription |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 75475.07 |
Authors | McGrath, S.,Tortorici, M.,Vidler, L.,Drouin, L.,Westwood, I.,Gimeson, P.,Van Montfort, R.,Hoelder, S. (deposition date: 2017-01-18, release date: 2017-04-05, Last modification date: 2024-01-17) |
Primary citation | McGrath, S.,Tortorici, M.,Drouin, L.,Solanki, S.,Vidler, L.,Westwood, I.,Gimeson, P.,Van Montfort, R.,Hoelder, S. Structure-Enabled Discovery of a Stapled Peptide Inhibitor to Target the Oncogenic Transcriptional Repressor TLE1. Chemistry, 23:9577-9584, 2017 Cited by PubMed: 28326635DOI: 10.1002/chem.201700747 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.04 Å) |
Structure validation
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