5MWJ
Structure Enabled Discovery of a Stapled Peptide Inhibitor to Target the Oncogenic Transcriptional Repressor TLE1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Transducin-like enhancer protein 1 | polymer | 337 | 36853.5 | 2 | UniProt (Q04724) Pfam (PF00400) | Homo sapiens (Human) | E(Sp1) homolog,Enhancer of split groucho-like protein 1,ESG1 |
| 2 | C (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 3 | D, E (A, B) | pepide inhibtor | non-polymer | 845.0 | 2 | Chemie (EBU) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 172 | Chemie (HOH) |
Sequence modifications
A, B: 443 - 770 (UniProt: Q04724)
| PDB | External Database | Details |
|---|---|---|
| Asp 434 | - | expression tag |
| Tyr 435 | - | expression tag |
| Phe 436 | - | expression tag |
| Gln 437 | - | expression tag |
| Gly 438 | - | expression tag |
| Ala 439 | - | expression tag |
| Met 440 | - | expression tag |
| Gly 441 | - | expression tag |
| Ser 442 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 73706.9 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1768.1 | |
| All* | Total formula weight | 75475.1 |
