5MWH
Crystal structure of the human BRPF1 bromodomain in complex with BZ089
Summary for 5MWH
| Entry DOI | 10.2210/pdb5mwh/pdb |
| Descriptor | Peregrin, ~{N}-[1,4-dimethyl-7-morpholin-4-yl-2,3-bis(oxidanylidene)quinoxalin-6-yl]-4-(2-methylpropyl)benzenesulfonamide, NITRATE ION, ... (4 entities in total) |
| Functional Keywords | bromodomain and phd finger-containing protein 1(brpf1), monocytic leukemia zinc-finger (moz), inhibitor, transcription, dna binding protein |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 2 |
| Total formula weight | 28504.57 |
| Authors | Zhu, J.,Caflisch, A. (deposition date: 2017-01-18, release date: 2018-02-14, Last modification date: 2019-10-16) |
| Primary citation | Zhu, J.,Zhou, C.,Caflisch, A. Structure-based discovery of selective BRPF1 bromodomain inhibitors. Eur J Med Chem, 155:337-352, 2018 Cited by PubMed: 29902720DOI: 10.1016/j.ejmech.2018.05.037 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
Download full validation report
