5MW2

CRYSTAL STRUCTURE OF BCL-6 BTB-domain with BI-3802

Summary for 5MW2

Entry DOI	10.2210/pdb5mw2/pdb
Descriptor	B-cell lymphoma 6 protein, 2-[6-[[5-chloranyl-2-[(3~{S},5~{R})-3,5-dimethylpiperidin-1-yl]pyrimidin-4-yl]amino]-1-methyl-2-oxidanylidene-quinolin-3-yl]oxy-~{N}-methyl-ethanamide (3 entities in total)
Functional Keywords	transcription, inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Nucleus : P41182
Total number of polymer chains	1
Total formula weight	14987.75
Authors	Bader, G.,Flotzinger, G.,Weiss-Puxbaum, A.,Zoephel, A. (deposition date: 2017-01-18, release date: 2017-10-04)
Primary citation	Kerres, N.,Steurer, S.,Schlager, S.,Bader, G.,Berger, H.,Caligiuri, M.,Dank, C.,Engen, J.R.,Ettmayer, P.,Fischerauer, B.,Flotzinger, G.,Gerlach, D.,Gerstberger, T.,Gmaschitz, T.,Greb, P.,Han, B.,Heyes, E.,Iacob, R.E.,Kessler, D.,Kolle, H.,Lamarre, L.,Lancia, D.R.,Lucas, S.,Mayer, M.,Mayr, K.,Mischerikow, N.,Muck, K.,Peinsipp, C.,Petermann, O.,Reiser, U.,Rudolph, D.,Rumpel, K.,Salomon, C.,Scharn, D.,Schnitzer, R.,Schrenk, A.,Schweifer, N.,Thompson, D.,Traxler, E.,Varecka, R.,Voss, T.,Weiss-Puxbaum, A.,Winkler, S.,Zheng, X.,Zoephel, A.,Kraut, N.,McConnell, D.,Pearson, M.,Koegl, M. Chemically Induced Degradation of the Oncogenic Transcription Factor BCL6. Cell Rep, 20:2860-2875, 2017 Cited by PubMed: 28930682 DOI: 10.1016/j.celrep.2017.08.081 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.35 Å)

Structure validation