5MW2

CRYSTAL STRUCTURE OF BCL-6 BTB-domain with BI-3802

5MW2 の概要

• エントリーDOI: 10.2210/pdb5mw2/pdb
• 分子名称: B-cell lymphoma 6 protein, 2-[6-[[5-chloranyl-2-[(3~{S},5~{R})-3,5-dimethylpiperidin-1-yl]pyrimidin-4-yl]amino]-1-methyl-2-oxidanylidene-quinolin-3-yl]oxy-~{N}-methyl-ethanamide (3 entities in total)
• 機能のキーワード: transcription, inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus : P41182
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 14987.75

構造登録者

Bader, G.,Flotzinger, G.,Weiss-Puxbaum, A.,Zoephel, A. (登録日: 2017-01-18, 公開日: 2017-10-04)

• 主引用文献: Kerres, N.,Steurer, S.,Schlager, S.,Bader, G.,Berger, H.,Caligiuri, M.,Dank, C.,Engen, J.R.,Ettmayer, P.,Fischerauer, B.,Flotzinger, G.,Gerlach, D.,Gerstberger, T.,Gmaschitz, T.,Greb, P.,Han, B.,Heyes, E.,Iacob, R.E.,Kessler, D.,Kolle, H.,Lamarre, L.,Lancia, D.R.,Lucas, S.,Mayer, M.,Mayr, K.,Mischerikow, N.,Muck, K.,Peinsipp, C.,Petermann, O.,Reiser, U.,Rudolph, D.,Rumpel, K.,Salomon, C.,Scharn, D.,Schnitzer, R.,Schrenk, A.,Schweifer, N.,Thompson, D.,Traxler, E.,Varecka, R.,Voss, T.,Weiss-Puxbaum, A.,Winkler, S.,Zheng, X.,Zoephel, A.,Kraut, N.,McConnell, D.,Pearson, M.,Koegl, M.; Chemically Induced Degradation of the Oncogenic Transcription Factor BCL6.; Cell Rep, 20:2860-2875, 2017; PubMed: 28930682; DOI: 10.1016/j.celrep.2017.08.081

実験手法

X-RAY DIFFRACTION (2.35 Å)