5MTF

A modular route to novel potent and selective inhibitors of rhomboid intramembrane proteases

5MTF の概要

• エントリーDOI: 10.2210/pdb5mtf/pdb
• 分子名称: Rhomboid protease GlpG, inhibitor, CHLORIDE ION, ... (5 entities in total)
• 機能のキーワード: rhomboid protease, specificity, inhibition, ketoamide, hydrolase
• 由来する生物種: Escherichia coli O45:K1 (strain S88 / ExPEC); 詳細
• 細胞内の位置: Cell inner membrane ; Multi-pass membrane protein : B7MDQ0
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 23930.46

構造登録者

Ticha, A.,Stanchev, S.,Vinothkumar, K.R.,Mikles, D.C.,Pachl, P.,Svehlova, K.,Nguyen, M.T.N.,Verhelst, S.H.L.,Johnson, D.,Bachovchin, D.,Lepsik, M.,Majer, P.,Strisovsky, K. (登録日: 2017-01-09, 公開日: 2017-11-15, 最終更新日: 2024-01-17)

• 主引用文献: Ticha, A.,Stanchev, S.,Vinothkumar, K.R.,Mikles, D.C.,Pachl, P.,Began, J.,Skerle, J.,Svehlova, K.,Nguyen, M.T.N.,Verhelst, S.H.L.,Johnson, D.C.,Bachovchin, D.A.,Lepsik, M.,Majer, P.,Strisovsky, K.; General and Modular Strategy for Designing Potent, Selective, and Pharmacologically Compliant Inhibitors of Rhomboid Proteases.; Cell Chem Biol, 24:1523-1536.e4, 2017; PubMed: 29107700; DOI: 10.1016/j.chembiol.2017.09.007

実験手法

X-RAY DIFFRACTION (1.79 Å)