5MT0

COMPLEMENT FACTOR D IN COMPLEX WITH A REVERSIBLE INDOLE CARBOXYLIC ACID BASED INHIBITOR

5MT0 の概要

• エントリーDOI: 10.2210/pdb5mt0/pdb
• 分子名称: Complement factor D, 5-fluoranyl-3-[[(1~{S},2~{S})-2-phenylcyclopropyl]carbonylamino]-1~{H}-indole-2-carboxylic acid, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 25173.52

構造登録者

Mac Sweeney, A.,Ostermann, N. (登録日: 2017-01-06, 公開日: 2017-02-15, 最終更新日: 2024-05-01)

• 主引用文献: Vulpetti, A.,Randl, S.,Rudisser, S.,Ostermann, N.,Erbel, P.,Mac Sweeney, A.,Zoller, T.,Salem, B.,Gerhartz, B.,Cumin, F.,Hommel, U.,Dalvit, C.,Lorthiois, E.,Maibaum, J.; Structure-Based Library Design and Fragment Screening for the Identification of Reversible Complement Factor D Protease Inhibitors.; J. Med. Chem., 60:1946-1958, 2017; PubMed: 28157311; DOI: 10.1021/acs.jmedchem.6b01684

実験手法

X-RAY DIFFRACTION (1.29 Å)