5MRO

Arabidopsis thaliana IspD Glu258Ala mutant in complex with Azolopyrimidine (1)

5MRO の概要

• エントリーDOI: 10.2210/pdb5mro/pdb
• 関連するPDBエントリー: 1W77 2YC5 4NAK
• 分子名称: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic, Azolopyrimidine, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (7 entities in total)
• 機能のキーワード: herbicide, anti-infectives, drug discovery, allosteric inhibition, mutant, transferase
• 由来する生物種: Arabidopsis thaliana (Mouse-ear cress)
• 細胞内の位置: Plastid, chloroplast stroma : P69834
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 26190.36

構造登録者

Schwab, A.,Illarionov, B.,Frank, A.,Kunfermann, A.,Seet, M.,Bacher, A.,Witschel, M.,Fischer, M.,Groll, M.,Diederich, F. (登録日: 2016-12-23, 公開日: 2017-07-19, 最終更新日: 2024-01-17)

• 主引用文献: Schwab, A.,Illarionov, B.,Frank, A.,Kunfermann, A.,Seet, M.,Bacher, A.,Witschel, M.C.,Fischer, M.,Groll, M.,Diederich, F.; Mechanism of Allosteric Inhibition of the Enzyme IspD by Three Different Classes of Ligands.; ACS Chem. Biol., 12:2132-2138, 2017; PubMed: 28686408; DOI: 10.1021/acschembio.7b00004

実験手法

X-RAY DIFFRACTION (1.8 Å)