5MRM
Arabidopsis thaliana IspD in complex with Isoxazole (4)
Summary for 5MRM
Entry DOI | 10.2210/pdb5mrm/pdb |
Related | 1W77 2YC5 4NAK |
Descriptor | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic, 2,4-bis(bromanyl)-6-[3-(trifluoromethyl)-1,2-oxazol-5-yl]phenol, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (7 entities in total) |
Functional Keywords | herbicide, anti-infectives, drug discovery, allosteric inhibition, transferase |
Biological source | Arabidopsis thaliana (Mouse-ear cress) |
Cellular location | Plastid, chloroplast stroma : P69834 |
Total number of polymer chains | 1 |
Total formula weight | 26413.76 |
Authors | Schwab, A.,Illarionov, B.,Frank, A.,Kunfermann, A.,Seet, M.,Bacher, A.,Witschel, M.,Fischer, M.,Groll, M.,Diederich, F. (deposition date: 2016-12-23, release date: 2017-07-19, Last modification date: 2024-01-17) |
Primary citation | Schwab, A.,Illarionov, B.,Frank, A.,Kunfermann, A.,Seet, M.,Bacher, A.,Witschel, M.C.,Fischer, M.,Groll, M.,Diederich, F. Mechanism of Allosteric Inhibition of the Enzyme IspD by Three Different Classes of Ligands. ACS Chem. Biol., 12:2132-2138, 2017 Cited by PubMed: 28686408DOI: 10.1021/acschembio.7b00004 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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