5MRK

Structural basis of Zika virus methyltransferase inhibition by sinefungin

5MRK の概要

• エントリーDOI: 10.2210/pdb5mrk/pdb
• 分子名称: methyltransferase, SINEFUNGIN, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: zika, virus, methyltransferase, sinefungin, transferase
• 由来する生物種: Zika virus (strain Mr 766) (ZIKV)
• 細胞内の位置: Virion membrane ; Multi-pass membrane protein : A0A1B0YUR2
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 59456.64

構造登録者

Hercik, K.,Boura, E. (登録日: 2016-12-23, 公開日: 2017-01-25, 最終更新日: 2024-10-23)

主引用文献

Hercik, K.,Brynda, J.,Nencka, R.,Boura, E.
Structural basis of Zika virus methyltransferase inhibition by sinefungin.
Arch. Virol., 162:2091-2096, 2017

PubMed Abstract: Zika virus is considered a major global threat to human kind. Here, we present a crystal structure of one of its essential enzymes, the methyltransferase, with the inhibitor sinefungin. This structure, together with previously solved structures with bound substrates, will provide the information needed for rational inhibitor design. Based on the structural data we suggest the modification of the adenine moiety of sinefungin to increase selectivity and to covalently link it to a GTP analogue, to increase the affinity of the synthesized compounds.

PubMed: 28357511
DOI: 10.1007/s00705-017-3345-x

実験手法

X-RAY DIFFRACTION (1.9 Å)