5MQV
Crystal structure of human Casein Kinase I delta in complex with 4-(2,5-Dimethoxyphenyl)-N-(4-(5-(4-fluorphenyl)-2-(methylthio)-1H-imidazol-4-yl)-pyridin-2-yl)-1-methyl-1H-pyrrole-2-carboxamide
Summary for 5MQV
Entry DOI | 10.2210/pdb5mqv/pdb |
Descriptor | Casein kinase I isoform delta, 4-(2,5-Dimethoxyphenyl)-N-(4-(5-(4-fluorphenyl)-2-(methylthio)-1H-imidazol-4-yl)-pyridin-2-yl)-1-methyl-1H-pyrrole-2-carboxamide, PHOSPHATE ION, ... (4 entities in total) |
Functional Keywords | ck1d, kinase-inhibitor complex, transferase, kinase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: P48730 |
Total number of polymer chains | 6 |
Total formula weight | 223523.39 |
Authors | Pichlo, C.,Brunstein, E.,Baumann, U. (deposition date: 2016-12-20, release date: 2017-04-05, Last modification date: 2024-01-17) |
Primary citation | Halekotte, J.,Witt, L.,Ianes, C.,Kruger, M.,Buhrmann, M.,Rauh, D.,Pichlo, C.,Brunstein, E.,Luxenburger, A.,Baumann, U.,Knippschild, U.,Bischof, J.,Peifer, C. Optimized 4,5-Diarylimidazoles as Potent/Selective Inhibitors of Protein Kinase CK1 delta and Their Structural Relation to p38 alpha MAPK. Molecules, 22:-, 2017 Cited by PubMed: 28338621DOI: 10.3390/molecules22040522 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.154 Å) |
Structure validation
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