5MQV

Crystal structure of human Casein Kinase I delta in complex with 4-(2,5-Dimethoxyphenyl)-N-(4-(5-(4-fluorphenyl)-2-(methylthio)-1H-imidazol-4-yl)-pyridin-2-yl)-1-methyl-1H-pyrrole-2-carboxamide

5MQV の概要

• エントリーDOI: 10.2210/pdb5mqv/pdb
• 分子名称: Casein kinase I isoform delta, 4-(2,5-Dimethoxyphenyl)-N-(4-(5-(4-fluorphenyl)-2-(methylthio)-1H-imidazol-4-yl)-pyridin-2-yl)-1-methyl-1H-pyrrole-2-carboxamide, PHOSPHATE ION, ... (4 entities in total)
• 機能のキーワード: ck1d, kinase-inhibitor complex, transferase, kinase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm: P48730
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 223523.39

構造登録者

Pichlo, C.,Brunstein, E.,Baumann, U. (登録日: 2016-12-20, 公開日: 2017-04-05, 最終更新日: 2024-01-17)

• 主引用文献: Halekotte, J.,Witt, L.,Ianes, C.,Kruger, M.,Buhrmann, M.,Rauh, D.,Pichlo, C.,Brunstein, E.,Luxenburger, A.,Baumann, U.,Knippschild, U.,Bischof, J.,Peifer, C.; Optimized 4,5-Diarylimidazoles as Potent/Selective Inhibitors of Protein Kinase CK1 delta and Their Structural Relation to p38 alpha MAPK.; Molecules, 22:-, 2017; PubMed: 28338621; DOI: 10.3390/molecules22040522

実験手法

X-RAY DIFFRACTION (2.154 Å)