5MPN
Crystal structure of CREBBP bromodomain complexed with FA26
Summary for 5MPN
Entry DOI | 10.2210/pdb5mpn/pdb |
Descriptor | CREB-binding protein, 1-[4-ethoxy-3-[3-(2~{H}-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]ethanone, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | crebbp bromodomain, inhibitor, transcription |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 14964.16 |
Authors | Zhu, J.,Caflisch, A. (deposition date: 2016-12-16, release date: 2018-01-17, Last modification date: 2024-05-08) |
Primary citation | Zhu, J.,Dong, J.,Batiste, L.,Unzue, A.,Dolbois, A.,Pascanu, V.,Sledz, P.,Nevado, C.,Caflisch, A. Binding Motifs in the CBP Bromodomain: An Analysis of 20 Crystal Structures of Complexes with Small Molecules. ACS Med Chem Lett, 9:929-934, 2018 Cited by PubMed: 30258543DOI: 10.1021/acsmedchemlett.8b00286 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.23 Å) |
Structure validation
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