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5MOT

Crystal structure of CK2alpha with ZT0627 bound

Summary for 5MOT
Entry DOI10.2210/pdb5mot/pdb
DescriptorCasein kinase II subunit alpha, 4-HYDROXYBENZAMIDE, ACETATE ION, ... (4 entities in total)
Functional Keywordsck2alpha, ck2a, fragment based drug discovery, high concentration screening, selective atp competitive inhibitors, surface entrophy reduction, transferase
Biological sourceHomo sapiens (Human)
Cellular locationNucleus : P68400
Total number of polymer chains1
Total formula weight39482.79
Authors
Brear, P.,De Fusco, C.,Georgiou, K.,Iegre, J.,Sore, H.,Hyvonen, M.,Spring, D. (deposition date: 2016-12-14, release date: 2017-05-24, Last modification date: 2024-01-17)
Primary citationDe Fusco, C.,Brear, P.,Iegre, J.,Georgiou, K.H.,Sore, H.F.,Hyvonen, M.,Spring, D.R.
A fragment-based approach leading to the discovery of a novel binding site and the selective CK2 inhibitor CAM4066.
Bioorg. Med. Chem., 25:3471-3482, 2017
Cited by
PubMed: 28495381
DOI: 10.1016/j.bmc.2017.04.037
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.09 Å)
Structure validation

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