5MMA

Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and the INSTI XZ379 (compound 5'g)

5MMA の概要

• エントリーDOI: 10.2210/pdb5mma/pdb
• 分子名称: integrase, HEXANE-1,6-DIOL, DNA (5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*CP*GP*CP*A)-3'), ... (11 entities in total)
• 機能のキーワード: hiv, pfv, prototype foamy virus, integrase, strand transfer, insti, tetramer intasome, integration, inhibitor, drug, viral protein
• 由来する生物種: Human spumaretrovirus (SFVcpz(hu)); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 102517.29

構造登録者

Maskell, D.P.,Pye, V.E.,Cherepanov, P. (登録日: 2016-12-09, 公開日: 2017-08-02, 最終更新日: 2024-01-17)

• 主引用文献: Zhao, X.Z.,Smith, S.J.,Maskell, D.P.,Metifiot, M.,Pye, V.E.,Fesen, K.,Marchand, C.,Pommier, Y.,Cherepanov, P.,Hughes, S.H.,Burke, T.R.; Structure-Guided Optimization of HIV Integrase Strand Transfer Inhibitors.; J. Med. Chem., 60:7315-7332, 2017; PubMed: 28737946; DOI: 10.1021/acs.jmedchem.7b00596

実験手法

X-RAY DIFFRACTION (2.55 Å)