5ML3

The crystal structure of PDE6D in complex to Deltasonamide1

Summary for 5ML3

Entry DOI	10.2210/pdb5ml3/pdb
Descriptor	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, ~{N}1-[(4-chlorophenyl)methyl]-~{N}1-cyclopentyl-~{N}4-[[2-(methylamino)pyrimidin-4-yl]methyl]-~{N}4-(piperidin-4-ylmethyl)benzene-1,4-disulfonamide (3 entities in total)
Functional Keywords	prenyl binding protein, farnesylated kras, plasma membrane, arl2, lipid binding protein
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm, cytosol : O43924
Total number of polymer chains	1
Total formula weight	17957.04
Authors	Fansa, E.K.,Martin-Gago, P.,Waldmann, H.,Wittinghofer, A. (deposition date: 2016-12-06, release date: 2017-02-01, Last modification date: 2024-01-17)
Primary citation	Martin-Gago, P.,Fansa, E.K.,Klein, C.H.,Murarka, S.,Janning, P.,Schurmann, M.,Metz, M.,Ismail, S.,Schultz-Fademrecht, C.,Baumann, M.,Bastiaens, P.I.,Wittinghofer, A.,Waldmann, H. A PDE6 delta-KRas Inhibitor Chemotype with up to Seven H-Bonds and Picomolar Affinity that Prevents Efficient Inhibitor Release by Arl2. Angew. Chem. Int. Ed. Engl., 56:2423-2428, 2017 Cited by PubMed: 28106325 DOI: 10.1002/anie.201610957 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.4 Å)

Structure validation