5MKX
1.68A STRUCTURE PCAF BROMODOMAIN WITH 4-chloro-2-methyl-5-(methylamino)pyridazin-3(2H)-one
Summary for 5MKX
Entry DOI | 10.2210/pdb5mkx/pdb |
Descriptor | Histone acetyltransferase KAT2B, 4-chloranyl-2-methyl-5-(methylamino)pyridazin-3-one, SULFATE ION, ... (6 entities in total) |
Functional Keywords | inhibitor, histone, epigenetic reader, bromodomain, pcaf, antagonist, transcription |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : Q92831 |
Total number of polymer chains | 2 |
Total formula weight | 29116.43 |
Authors | Chung, C.-W. (deposition date: 2016-12-05, release date: 2017-12-20, Last modification date: 2024-06-19) |
Primary citation | Humphreys, P.G.,Bamborough, P.,Chung, C.W.,Craggs, P.D.,Gordon, L.,Grandi, P.,Hayhow, T.G.,Hussain, J.,Jones, K.L.,Lindon, M.,Michon, A.M.,Renaux, J.F.,Suckling, C.J.,Tough, D.F.,Prinjha, R.K. Discovery of a Potent, Cell Penetrant, and Selective p300/CBP-Associated Factor (PCAF)/General Control Nonderepressible 5 (GCN5) Bromodomain Chemical Probe. J. Med. Chem., 60:695-709, 2017 Cited by PubMed: 28002667DOI: 10.1021/acs.jmedchem.6b01566 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.68 Å) |
Structure validation
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