5MKE

cryoEM Structure of Polycystin-2 in complex with cations and lipids

Summary for 5MKE

Entry DOI	10.2210/pdb5mke/pdb
EMDB information	3523
Descriptor	Polycystin-2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
Functional Keywords	ca2+ signaling, cryoem, membrane protein structure, polycystin-2, trp channel, transport protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	450236.71
Authors	Wilkes, M.,Madej, M.G.,Ziegler, C. (deposition date: 2016-12-04, release date: 2017-01-18, Last modification date: 2020-07-29)
Primary citation	Wilkes, M.,Madej, M.G.,Kreuter, L.,Rhinow, D.,Heinz, V.,De Sanctis, S.,Ruppel, S.,Richter, R.M.,Joos, F.,Grieben, M.,Pike, A.C.,Huiskonen, J.T.,Carpenter, E.P.,Kuhlbrandt, W.,Witzgall, R.,Ziegler, C. Molecular insights into lipid-assisted Ca(2+) regulation of the TRP channel Polycystin-2. Nat. Struct. Mol. Biol., 24:123-130, 2017 Cited by PubMed: 28092368 DOI: 10.1038/nsmb.3357 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (4.3 Å)

Structure validation