5MKE

cryoEM Structure of Polycystin-2 in complex with cations and lipids

5MKE の概要

• エントリーDOI: 10.2210/pdb5mke/pdb
• EMDBエントリー: 3523
• 分子名称: Polycystin-2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: ca2+ signaling, cryoem, membrane protein structure, polycystin-2, trp channel, transport protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 450236.71

構造登録者

Wilkes, M.,Madej, M.G.,Ziegler, C. (登録日: 2016-12-04, 公開日: 2017-01-18, 最終更新日: 2020-07-29)

• 主引用文献: Wilkes, M.,Madej, M.G.,Kreuter, L.,Rhinow, D.,Heinz, V.,De Sanctis, S.,Ruppel, S.,Richter, R.M.,Joos, F.,Grieben, M.,Pike, A.C.,Huiskonen, J.T.,Carpenter, E.P.,Kuhlbrandt, W.,Witzgall, R.,Ziegler, C.; Molecular insights into lipid-assisted Ca(2+) regulation of the TRP channel Polycystin-2.; Nat. Struct. Mol. Biol., 24:123-130, 2017; PubMed: 28092368; DOI: 10.1038/nsmb.3357

実験手法

ELECTRON MICROSCOPY (4.3 Å)