5MJ6

Ligand-induced conformational change of Insulin-regulated aminopeptidase: insights on catalytic mechanism and active site plasticity.

Summary for 5MJ6

• Entry DOI: 10.2210/pdb5mj6/pdb
• Descriptor: Leucyl-cystinyl aminopeptidase, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
• Functional Keywords: insulin-regulated aminopeptidase, endoplasmatic reticulum aminopeptidases, generation of antigenic peptides for cross-presentation, phosphinic pseudotripeptides, ligand-induced conformational changes, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 217245.27

Authors

Mpakali, A.,Stratikos, E.,Saridakis, E.,Giastas, P. (deposition date: 2016-11-30, release date: 2017-04-05, Last modification date: 2024-01-17)

• Primary citation: Mpakali, A.,Saridakis, E.,Harlos, K.,Zhao, Y.,Kokkala, P.,Georgiadis, D.,Giastas, P.,Papakyriakou, A.,Stratikos, E.; Ligand-Induced Conformational Change of Insulin-Regulated Aminopeptidase: Insights on Catalytic Mechanism and Active Site Plasticity.; J. Med. Chem., 60:2963-2972, 2017; PubMed: 28328206; DOI: 10.1021/acs.jmedchem.6b01890

Experimental method

X-RAY DIFFRACTION (2.53 Å)