5MJ6

Ligand-induced conformational change of Insulin-regulated aminopeptidase: insights on catalytic mechanism and active site plasticity.

5MJ6 の概要

• エントリーDOI: 10.2210/pdb5mj6/pdb
• 分子名称: Leucyl-cystinyl aminopeptidase, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
• 機能のキーワード: insulin-regulated aminopeptidase, endoplasmatic reticulum aminopeptidases, generation of antigenic peptides for cross-presentation, phosphinic pseudotripeptides, ligand-induced conformational changes, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 217245.27

構造登録者

Mpakali, A.,Stratikos, E.,Saridakis, E.,Giastas, P. (登録日: 2016-11-30, 公開日: 2017-04-05, 最終更新日: 2024-01-17)

• 主引用文献: Mpakali, A.,Saridakis, E.,Harlos, K.,Zhao, Y.,Kokkala, P.,Georgiadis, D.,Giastas, P.,Papakyriakou, A.,Stratikos, E.; Ligand-Induced Conformational Change of Insulin-Regulated Aminopeptidase: Insights on Catalytic Mechanism and Active Site Plasticity.; J. Med. Chem., 60:2963-2972, 2017; PubMed: 28328206; DOI: 10.1021/acs.jmedchem.6b01890

実験手法

X-RAY DIFFRACTION (2.53 Å)