5MGV
Kinetic and Structural Changes in HsmtPheRS, Induced by Pathogenic Mutations in Human FARS2
Summary for 5MGV
Entry DOI | 10.2210/pdb5mgv/pdb |
Descriptor | Phenylalanine--tRNA ligase, mitochondrial (2 entities in total) |
Functional Keywords | crystal structure of pathogenic human mitochondrial phers, molecular dynamic, kinetik study, aminoacylation, ligase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 47519.94 |
Authors | Kartvelishvili, E.,Tworowski, D.,Vernon, H.,Chrzanowska-Lightowlers, Z.,Moor, N.,Wang, J.,Wong, L.-J.,Safro, M. (deposition date: 2016-11-22, release date: 2017-05-03, Last modification date: 2024-05-08) |
Primary citation | Kartvelishvili, E.,Tworowski, D.,Vernon, H.,Moor, N.,Wang, J.,Wong, L.J.,Chrzanowska-Lightowlers, Z.,Safro, M. Kinetic and structural changes in HsmtPheRS, induced by pathogenic mutations in human FARS2. Protein Sci., 26:1505-1516, 2017 Cited by PubMed: 28419689DOI: 10.1002/pro.3176 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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