5M7U
Structure of human O-GlcNAc hydrolase with new iminocyclitol type inhibitor
Summary for 5M7U
Entry DOI | 10.2210/pdb5m7u/pdb |
Descriptor | Protein O-GlcNAcase, 2-[(2~{R},3~{S},4~{R},5~{R})-5-(hydroxymethyl)-3,4-bis(oxidanyl)-1-[3-[3-(trifluoromethyl)phenyl]propyl]pyrrolidin-2-yl]-~{N}-methyl-ethanamide (3 entities in total) |
Functional Keywords | human glycoside hydrolase, glcnac, hydrolase |
Biological source | Homo sapiens (Human) |
Cellular location | Isoform 3: Nucleus . Isoform 1: Cytoplasm : O60502 |
Total number of polymer chains | 2 |
Total formula weight | 206822.61 |
Authors | Roth, C.,Chan, S.,Offen, W.A.,Hemsworth, G.R.,Willems, L.I.,King, D.,Varghese, V.,Britton, R.,Vocadlo, D.J.,Davies, G.J. (deposition date: 2016-10-28, release date: 2017-03-29, Last modification date: 2024-01-17) |
Primary citation | Roth, C.,Chan, S.,Offen, W.A.,Hemsworth, G.R.,Willems, L.I.,King, D.T.,Varghese, V.,Britton, R.,Vocadlo, D.J.,Davies, G.J. Structural and functional insight into human O-GlcNAcase. Nat. Chem. Biol., 13:610-612, 2017 Cited by PubMed: 28346405DOI: 10.1038/nchembio.2358 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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