5M5G

Crystal structure of the Chaetomium Thermophilum polycomb repressive complex 2 (PRC2)

5M5G の概要

• エントリーDOI: 10.2210/pdb5m5g/pdb
• 分子名称: putative polycomb protein EED, Putative uncharacterized protein, HISTONE H3 11-Mer peptide, ... (7 entities in total)
• 機能のキーワード: transferase, repressive, complex
• 由来する生物種: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 175871.17

構造登録者

Zhang, Y.,Justin, N.,Wilson, J.,Gamblin, S. (登録日: 2016-10-21, 公開日: 2017-01-11, 最終更新日: 2025-04-09)

主引用文献

Zhang, Y.,Justin, N.,Wilson, J.R.,Gamblin, S.J.
Comment on "Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2".
Science, 354:1543-1543, 2016

PubMed Abstract: Jiao and Liu (Research Articles, 16 October 2015, aac4383) reported the crystal structure of the protein complex polycomb repressive complex 2 from Chaetomium thermophilum This landmark structure has brought invaluable insights into the activation mechanism of this essential methyltransferase. However, the analysis of the x-ray data discussed below suggests that the description of oncogenic H3K27M peptide binding to the active site is incorrect.

PubMed: 28008037
DOI: 10.1126/science.aaf6236

実験手法

X-RAY DIFFRACTION (2.27 Å)