5M53

Nek2 bound to arylaminopurine inhibitor 11

Summary for 5M53

• Entry DOI: 10.2210/pdb5m53/pdb
• Descriptor: Serine/threonine-protein kinase Nek2, 3-[[6-(cyclohexylmethoxy)-7~{H}-purin-2-yl]amino]-~{N},~{N}-dimethyl-benzamide, DI(HYDROXYETHYL)ETHER, ... (6 entities in total)
• Functional Keywords: protein kinase, inhibitor, centrosome separation, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Isoform 1: Nucleus. Isoform 2: Cytoplasm. Isoform 4: Nucleus: P51955
• Total number of polymer chains: 1
• Total formula weight: 33991.45

Authors

Bayliss, R.,Carr, K.H. (deposition date: 2016-10-20, release date: 2016-11-09, Last modification date: 2024-01-17)

• Primary citation: Coxon, C.R.,Wong, C.,Bayliss, R.,Boxall, K.,Carr, K.H.,Fry, A.M.,Hardcastle, I.R.,Matheson, C.J.,Newell, D.R.,Sivaprakasam, M.,Thomas, H.,Turner, D.,Yeoh, S.,Wang, L.Z.,Griffin, R.J.,Golding, B.T.,Cano, C.; Structure-guided design of purine-based probes for selective Nek2 inhibition.; Oncotarget, 8:19089-19124, 2017; PubMed: 27833088; DOI: 10.18632/oncotarget.13249

Experimental method

X-RAY DIFFRACTION (1.9 Å)