5M4Z
Crystal structure of the complex of T.spiralis thymidylate synthase with N(4)-hydroxy-2'-deoxycytidine-5'-monophosphate, crystallized in the presence of N(5,10)-methylenetetrahydrofolate
Summary for 5M4Z
Entry DOI | 10.2210/pdb5m4z/pdb |
Descriptor | Thymidylate synthase, [(2~{R},3~{S},5~{R})-5-[(4~{E})-4-hydroxyimino-2-oxidanylidene-1,3-diazinan-1-yl]-3-oxidanyl-oxolan-2-yl]methyl dihydrogen phosphate, GLYCEROL, ... (4 entities in total) |
Functional Keywords | enzyme-inhibitor complex, high-resolution structure, anticancer target, transferase |
Biological source | Trichinella spiralis (Trichina worm) |
Total number of polymer chains | 2 |
Total formula weight | 75591.64 |
Authors | Wilk, P.,Maj, P.,Jarmula, A.,Dowiercial, A.,Rode, W. (deposition date: 2016-10-19, release date: 2017-12-20, Last modification date: 2024-01-17) |
Primary citation | Maj, P.,Jarmula, A.,Wilk, P.,Prokopowicz, M.,Rypniewski, W.,Zielinski, Z.,Dowiercial, A.,Bzowska, A.,Rode, W. Molecular Mechanism of Thymidylate Synthase Inhibition by N 4 -Hydroxy-dCMP in View of Spectrophotometric and Crystallographic Studies. Int J Mol Sci, 22:-, 2021 Cited by PubMed: 33946210DOI: 10.3390/ijms22094758 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.179 Å) |
Structure validation
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