5M4Z
Crystal structure of the complex of T.spiralis thymidylate synthase with N(4)-hydroxy-2'-deoxycytidine-5'-monophosphate, crystallized in the presence of N(5,10)-methylenetetrahydrofolate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004146 | molecular_function | dihydrofolate reductase activity |
| A | 0004799 | molecular_function | thymidylate synthase activity |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005829 | cellular_component | cytosol |
| A | 0006231 | biological_process | dTMP biosynthetic process |
| A | 0006235 | biological_process | dTTP biosynthetic process |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0009165 | biological_process | nucleotide biosynthetic process |
| A | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
| A | 0032259 | biological_process | methylation |
| B | 0004146 | molecular_function | dihydrofolate reductase activity |
| B | 0004799 | molecular_function | thymidylate synthase activity |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005829 | cellular_component | cytosol |
| B | 0006231 | biological_process | dTMP biosynthetic process |
| B | 0006235 | biological_process | dTTP biosynthetic process |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0009165 | biological_process | nucleotide biosynthetic process |
| B | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
| B | 0032259 | biological_process | methylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | binding site for residue 7K8 A 401 |
| Chain | Residue |
| A | TYR129 |
| A | HIS250 |
| A | TYR252 |
| A | HOH502 |
| A | HOH553 |
| B | ARG169 |
| B | ARG170 |
| B | HOH578 |
| A | CYS189 |
| A | HIS190 |
| A | GLN208 |
| A | ARG209 |
| A | SER210 |
| A | ALA211 |
| A | ASP212 |
| A | ASN220 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 402 |
| Chain | Residue |
| A | GLN29 |
| A | THR54 |
| A | GLN55 |
| A | SER56 |
| A | TYR58 |
| A | ILE221 |
| A | HIS244 |
| A | ILE246 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 403 |
| Chain | Residue |
| A | TYR152 |
| A | GLN154 |
| A | GLN157 |
| A | MET161 |
| A | ARG170 |
| A | ILE172 |
| A | HOH510 |
| B | TRP176 |
| B | LEU181 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 404 |
| Chain | Residue |
| A | ALA92 |
| A | LYS93 |
| A | SER96 |
| A | ASP104 |
| A | SER107 |
| A | SER108 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | binding site for residue GOL B 402 |
| Chain | Residue |
| A | TRP176 |
| A | LEU181 |
| B | TYR152 |
| B | GLN154 |
| B | GLN157 |
| B | MET161 |
| B | ARG170 |
| B | ILE172 |
| B | HOH544 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 403 |
| Chain | Residue |
| A | ARG57 |
| A | TYR196 |
| A | SER203 |
| A | ILE243 |
| A | HOH515 |
| B | THR51 |
| B | PHE52 |
| site_id | AC7 |
| Number of Residues | 19 |
| Details | binding site for Di-peptide 7K8 B 401 and CYS B 189 |
| Chain | Residue |
| A | ARG169 |
| A | ARG170 |
| B | ARG43 |
| B | TRP103 |
| B | TYR129 |
| B | PRO187 |
| B | PRO188 |
| B | HIS190 |
| B | CYS191 |
| B | GLN208 |
| B | ARG209 |
| B | SER210 |
| B | ALA211 |
| B | ASP212 |
| B | ASN220 |
| B | HIS250 |
| B | TYR252 |
| B | HOH502 |
| B | HOH568 |
Functional Information from PROSITE/UniProt
| site_id | PS00091 |
| Number of Residues | 29 |
| Details | THYMIDYLATE_SYNTHASE Thymidylate synthase active site. RriImtaWNpcdlekva.....LpPCHcfvQFyV |
| Chain | Residue | Details |
| A | ARG169-VAL197 |
