5M39
Crystal structure of BRD4 BROMODOMAIN 1 IN COMPLEX WITH LIGAND 1
Summary for 5M39
| Entry DOI | 10.2210/pdb5m39/pdb |
| Descriptor | Bromodomain-containing protein 4, 6-(3,4-dimethoxyphenyl)-3-methyl-[1,2,4]triazolo[4,3-b]pyridazine (3 entities in total) |
| Functional Keywords | bromodomain, brd4 bd1, epigenetic, histone reader, transcription |
| Biological source | Homo sapiens (Human) |
| Cellular location | Nucleus: O60885 |
| Total number of polymer chains | 2 |
| Total formula weight | 30739.33 |
| Authors | Kessler, D.,Mayer, M.,Engelhardt, H.,Wolkerstorfer, B.,Geist, L. (deposition date: 2016-10-14, release date: 2017-09-27, Last modification date: 2024-01-17) |
| Primary citation | Geist, L.,Mayer, M.,Cockcroft, X.L.,Wolkerstorfer, B.,Kessler, D.,Engelhardt, H.,McConnell, D.B.,Konrat, R. Direct NMR Probing of Hydration Shells of Protein Ligand Interfaces and Its Application to Drug Design. J. Med. Chem., 60:8708-8715, 2017 Cited by PubMed: 28910100DOI: 10.1021/acs.jmedchem.7b00845 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.38 Å) |
Structure validation
Download full validation report
