5M2F
Crystal structure of human AKR1B10 complexed with NADP+ and the synthetic retinoid UVI2008
Summary for 5M2F
Entry DOI | 10.2210/pdb5m2f/pdb |
Related | 1ZUA |
Descriptor | Aldo-keto reductase family 1 member B10, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-bromo-4-[(1E)-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)prop-1-en-1-yl]benzoic acid, ... (5 entities in total) |
Functional Keywords | tim barrel, aldo-keto reductase, oxidoreductase, synthetic retinoid, cytosolic |
Biological source | Homo sapiens (Human) |
Cellular location | Lysosome : O60218 |
Total number of polymer chains | 1 |
Total formula weight | 37679.97 |
Authors | Ruiz, F.X.,Cousido-Siah, A.,Mitschler, A.,Porte, S.,Alvarez, S.,Dominguez, M.,Alvarez, R.,de Lera, A.R.,Pares, X.,Farres, J.,Podjarny, A. (deposition date: 2016-10-12, release date: 2017-02-15, Last modification date: 2024-01-17) |
Primary citation | Ruiz, F.X.,Crespo, I.,Alvarez, S.,Porte, S.,Gimenez-Dejoz, J.,Cousido-Siah, A.,Mitschler, A.,de Lera, A.R.,Pares, X.,Podjarny, A.,Farres, J. Structural basis for the inhibition of AKR1B10 by the C3 brominated TTNPB derivative UVI2008. Chem. Biol. Interact., 276:174-181, 2017 Cited by PubMed: 28161411DOI: 10.1016/j.cbi.2017.01.026 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.503 Å) |
Structure validation
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