5LZG

Cholera toxin El Tor B-pentamer in complex with inhibitor PC262

Summary for 5LZG

Entry DOI	10.2210/pdb5lzg/pdb
Descriptor	Cholera enterotoxin subunit B, (2~{R},4~{S},5~{R},6~{R})-5-acetamido-2-[4-[3-[2-[(2~{S},3~{R},4~{R},5~{R},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]ethylamino]-3-oxidanylidene-propyl]-1,2,3-triazol-1-yl]-4-oxidanyl-6-[(1~{R},2~{R})-1,2,3-tris(oxidanyl)propyl]oxane-2-carboxylic acid, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (7 entities in total)
Functional Keywords	cholera toxin b-pentamer, inhibitor, toxin
Biological source	Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Cellular location	Secreted: P01556
Total number of polymer chains	5
Total formula weight	61894.31
Authors	Heggelund, J.E.,Martinsen, T.,Krengel, U. (deposition date: 2016-09-29, release date: 2017-05-31, Last modification date: 2024-01-17)
Primary citation	Heggelund, J.E.,Mackenzie, A.,Martinsen, T.,Benjamin Heim, J.,Cheshev, P.,Bernardi, A.,Krengel, U. Towards new cholera prophylactics and treatment: Crystal structures of bacterial enterotoxins in complex with GM1 mimics. Sci Rep, 7:2326-2326, 2017 Cited by PubMed: 28539625 DOI: 10.1038/s41598-017-02179-0 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.13 Å)

Structure validation