5LWP
Discovery of phenoxyindazoles and phenylthioindazoles as RORg inverse agonists
Summary for 5LWP
Entry DOI | 10.2210/pdb5lwp/pdb |
Descriptor | Nuclear receptor ROR-gamma, 4-[3-[2-chloranyl-6-(trifluoromethyl)phenoxy]-5-(dimethylcarbamoyl)indazol-1-yl]benzoic acid (3 entities in total) |
Functional Keywords | ror gamma allosteric ligand inverse agonistm, transcription |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : P51449 |
Total number of polymer chains | 1 |
Total formula weight | 28993.94 |
Authors | Ouvry, G.,Bouix-Peter, C.,Ciesielski, F.,Chantalat, L.,Christin, O.,Comino, C.,Duvert, D.,Feret, C.,Harris, C.S.,Luzy, A.-P.,Musicki, B.,Orfila, D.,Pascau, J.,Parnet, V.,Perrin, A.,Pierre, R.,Raffin, C.,Rival, Y.,Taquet, N.,Thoreau, E.,Hennequin, L.F. (deposition date: 2016-09-19, release date: 2016-11-16, Last modification date: 2024-01-17) |
Primary citation | Ouvry, G.,Bouix-Peter, C.,Ciesielski, F.,Chantalat, L.,Christin, O.,Comino, C.,Duvert, D.,Feret, C.,Harris, C.S.,Lamy, L.,Luzy, A.P.,Musicki, B.,Orfila, D.,Pascau, J.,Parnet, V.,Perrin, A.,Pierre, R.,Polge, G.,Raffin, C.,Rival, Y.,Taquet, N.,Thoreau, E.,Hennequin, L.F. Discovery of phenoxyindazoles and phenylthioindazoles as ROR gamma inverse agonists. Bioorg.Med.Chem.Lett., 26:5802-5808, 2016 Cited by PubMed: 27815118DOI: 10.1016/j.bmcl.2016.10.023 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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