5LWP

Discovery of phenoxyindazoles and phenylthioindazoles as RORg inverse agonists

5LWP の概要

• エントリーDOI: 10.2210/pdb5lwp/pdb
• 分子名称: Nuclear receptor ROR-gamma, 4-[3-[2-chloranyl-6-(trifluoromethyl)phenoxy]-5-(dimethylcarbamoyl)indazol-1-yl]benzoic acid (3 entities in total)
• 機能のキーワード: ror gamma allosteric ligand inverse agonistm, transcription
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus : P51449
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 28993.94

構造登録者

Ouvry, G.,Bouix-Peter, C.,Ciesielski, F.,Chantalat, L.,Christin, O.,Comino, C.,Duvert, D.,Feret, C.,Harris, C.S.,Luzy, A.-P.,Musicki, B.,Orfila, D.,Pascau, J.,Parnet, V.,Perrin, A.,Pierre, R.,Raffin, C.,Rival, Y.,Taquet, N.,Thoreau, E.,Hennequin, L.F. (登録日: 2016-09-19, 公開日: 2016-11-16, 最終更新日: 2024-01-17)

• 主引用文献: Ouvry, G.,Bouix-Peter, C.,Ciesielski, F.,Chantalat, L.,Christin, O.,Comino, C.,Duvert, D.,Feret, C.,Harris, C.S.,Lamy, L.,Luzy, A.P.,Musicki, B.,Orfila, D.,Pascau, J.,Parnet, V.,Perrin, A.,Pierre, R.,Polge, G.,Raffin, C.,Rival, Y.,Taquet, N.,Thoreau, E.,Hennequin, L.F.; Discovery of phenoxyindazoles and phenylthioindazoles as ROR gamma inverse agonists.; Bioorg.Med.Chem.Lett., 26:5802-5808, 2016; PubMed: 27815118; DOI: 10.1016/j.bmcl.2016.10.023

実験手法

X-RAY DIFFRACTION (2.4 Å)