5LUA

Crystal structure of human legumain (AEP) in complex with compound 11b

Summary for 5LUA

• Entry DOI: 10.2210/pdb5lua/pdb
• Descriptor: Legumain, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: cysteine protease, allosteric inhibitor, asparaginyl endopeptidase, alzheimer's disease, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 61868.11

Authors

Dall, E.,Ye, K.,Brandstetter, H. (deposition date: 2016-09-08, release date: 2017-03-29, Last modification date: 2024-01-17)

• Primary citation: Zhang, Z.,Obianyo, O.,Dall, E.,Du, Y.,Fu, H.,Liu, X.,Kang, S.S.,Song, M.,Yu, S.P.,Cabrele, C.,Schubert, M.,Li, X.,Wang, J.Z.,Brandstetter, H.,Ye, K.; Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease.; Nat Commun, 8:14740-14740, 2017; PubMed: 28345579; DOI: 10.1038/ncomms14740

Experimental method

X-RAY DIFFRACTION (2 Å)