5LU9

Crystal structure of YVAD-cmk bound human legumain (AEP) in complex with compound 11

5LU9 の概要

• エントリーDOI: 10.2210/pdb5lu9/pdb
• 関連するBIRD辞書のPRD_ID: PRD_002086
• 分子名称: AC-TYR-VAL-ALA-ASP-CHLOROMETHYLKETONE, Legumain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: cysteine protease, allosteric inhibitor, asparaginyl endopeptidase, alzheimer's disease, hydrolase
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 31481.54

構造登録者

Dall, E.,Ye, K.,Brandstetter, H. (登録日: 2016-09-08, 公開日: 2017-03-29, 最終更新日: 2024-01-17)

• 主引用文献: Zhang, Z.,Obianyo, O.,Dall, E.,Du, Y.,Fu, H.,Liu, X.,Kang, S.S.,Song, M.,Yu, S.P.,Cabrele, C.,Schubert, M.,Li, X.,Wang, J.Z.,Brandstetter, H.,Ye, K.; Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease.; Nat Commun, 8:14740-14740, 2017; PubMed: 28345579; DOI: 10.1038/ncomms14740

実験手法

X-RAY DIFFRACTION (2.27 Å)