5LSS
Structure of the Epigenetic Oncogene MMSET and inhibition by N-Alkyl Sinefungin Derivatives
Summary for 5LSS
Entry DOI | 10.2210/pdb5lss/pdb |
Descriptor | Histone-lysine N-methyltransferase SETD2, ZINC ION, THIOCYANATE ION, ... (5 entities in total) |
Functional Keywords | lysine methyltransferase, mmset, setd2, set domain, setd2#1, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 34778.60 |
Authors | Tisi, D.,Pathuri, P. (deposition date: 2016-09-05, release date: 2016-10-05, Last modification date: 2024-05-08) |
Primary citation | Tisi, D.,Chiarparin, E.,Tamanini, E.,Pathuri, P.,Coyle, J.E.,Hold, A.,Holding, F.P.,Amin, N.,Martin, A.C.,Rich, S.J.,Berdini, V.,Yon, J.,Acklam, P.,Burke, R.,Drouin, L.,Harmer, J.E.,Jeganathan, F.,van Montfort, R.L.,Newbatt, Y.,Tortorici, M.,Westlake, M.,Wood, A.,Hoelder, S.,Heightman, T.D. Structure of the Epigenetic Oncogene MMSET and Inhibition by N-Alkyl Sinefungin Derivatives. ACS Chem. Biol., 11:3093-3105, 2016 Cited by PubMed: 27571355DOI: 10.1021/acschembio.6b00308 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.79 Å) |
Structure validation
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