5LRE

Crystal structure of Glycogen Phosphorylase b in complex with KS382

Summary for 5LRE

• Entry DOI: 10.2210/pdb5lre/pdb
• Related: 5LRD
• Descriptor: Glycogen phosphorylase, muscle form, (2~{R},3~{S},4~{R},5~{R},6~{S})-2-(hydroxymethyl)-6-(3-naphthalen-2-yl-1~{H}-1,2,4-triazol-5-yl)oxane-3,4,5-triol, PYRIDOXAL-5'-PHOSPHATE, ... (5 entities in total)
• Functional Keywords: transferase, alpha and beta protein
• Biological source: Oryctolagus cuniculus (Rabbit)
• Total number of polymer chains: 1
• Total formula weight: 98409.33

Authors

Kantsadi, A.L.,Stravodimos, G.A.,Kyriakis, E.,Chatzileontiadou, D.S.M.,Leonidas, D.D. (deposition date: 2016-08-18, release date: 2017-05-31, Last modification date: 2018-01-17)

• Primary citation: Kantsadi, A.L.,Bokor, E.,Kun, S.,Stravodimos, G.A.,Chatzileontiadou, D.S.,Leonidas, D.D.,Juhasz-Toth, E.,Szakacs, A.,Batta, G.,Docsa, T.,Gergely, P.,Somsak, L.; Synthetic, enzyme kinetic, and protein crystallographic studies of C-beta-d-glucopyranosyl pyrroles and imidazoles reveal and explain low nanomolar inhibition of human liver glycogen phosphorylase.; Eur J Med Chem, 123:737-745, 2016; PubMed: 27522507; DOI: 10.1016/j.ejmech.2016.06.049

Experimental method

X-RAY DIFFRACTION (1.8 Å)