5LQN

Crystal Structure of COMT in complex with 2-[(3-chlorophenoxy)methyl]-4-methyl-5-(1H-pyrazol-5-yl)-1,3-thiazole

Summary for 5LQN

• Entry DOI: 10.2210/pdb5lqn/pdb
• Descriptor: Catechol O-methyltransferase, 2-[(3-chloranylphenoxy)methyl]-4-methyl-5-(1~{H}-pyrazol-5-yl)-1,3-thiazole (3 entities in total)
• Functional Keywords: methyltransferase, neurotransmitter degradation, transferase
• Biological source: Rattus norvegicus (norway Rat)
• Cellular location: Isoform 2: Cytoplasm. Isoform 1: Cell membrane; Single-pass type II membrane protein; Extracellular side: P22734
• Total number of polymer chains: 1
• Total formula weight: 25000.11

Authors

Ehler, A.,Lerner, C.,Rudolph, M.G. (deposition date: 2016-08-17, release date: 2016-10-05)

• Primary citation: Lerner, C.,Rudolph, M.G.; Crystal Structure of COMT in complex with 2-[(3-chlorophenoxy)methyl]-4-methyl-5-(1H-pyrazol-5-yl)-1,3-thiazole; To be published,

Experimental method

X-RAY DIFFRACTION (1.72 Å)