5LQF

CDK1/CyclinB1/CKS2 in complex with NU6102

5LQF の概要

• エントリーDOI: 10.2210/pdb5lqf/pdb
• 分子名称: Cyclin-dependent kinase 1, G2/mitotic-specific cyclin-B1, Cyclin-dependent kinases regulatory subunit 2, ... (5 entities in total)
• 機能のキーワード: cdk1 cyclin b cks2 cell cycle nu6102, transferase
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Nucleus: P06493; Cytoplasm: P14635
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 153233.71

構造登録者

Coxon, C.R.,Anscombe, E.,Harnor, S.J.,Martin, M.P.,Carbain, B.J.,Hardcastle, I.R.,Harlow, L.K.,Korolchuk, S.,Matheson, C.J.,Noble, M.E.,Newell, D.R.,Turner, D.M.,Sivaprakasam, M.,Wang, L.Z.,Wong, C.,Golding, B.T.,Griffin, R.J.,Endicott, J.A.,Cano, C. (登録日: 2016-08-17, 公開日: 2017-01-11, 最終更新日: 2024-01-10)

• 主引用文献: Coxon, C.R.,Anscombe, E.,Harnor, S.J.,Martin, M.P.,Carbain, B.,Golding, B.T.,Hardcastle, I.R.,Harlow, L.K.,Korolchuk, S.,Matheson, C.J.,Newell, D.R.,Noble, M.E.,Sivaprakasam, M.,Tudhope, S.J.,Turner, D.M.,Wang, L.Z.,Wedge, S.R.,Wong, C.,Griffin, R.J.,Endicott, J.A.,Cano, C.; Cyclin-Dependent Kinase (CDK) Inhibitors: Structure-Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines.; J. Med. Chem., 60:1746-1767, 2017; PubMed: 28005359; DOI: 10.1021/acs.jmedchem.6b01254

実験手法

X-RAY DIFFRACTION (2.06 Å)