5LQA

rat catechol O-methyltransferase at high pH in complex with a bisubstrate inhibitor

Summary for 5LQA

• Entry DOI: 10.2210/pdb5lqa/pdb
• Descriptor: Catechol O-methyltransferase, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, N-[(E)-3-[(2R,3S,4R,5R)-5-(6-ethylaminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]prop-2-enyl]-5-(4-fluorophenyl)-2,3-dihydroxy-benzamide, ... (7 entities in total)
• Functional Keywords: methyltransferase, neurotransmitter degradation, transferase
• Biological source: Rattus norvegicus (Rat)
• Cellular location: Isoform 2: Cytoplasm. Isoform 1: Cell membrane; Single-pass type II membrane protein; Extracellular side: P22734
• Total number of polymer chains: 1
• Total formula weight: 25026.70

Authors

Ehler, A.,Ellermann, M.,Rudolph, M.G. (deposition date: 2016-08-16, release date: 2016-10-05)

• Primary citation: Ellermann, M.,Rudolph, M.G.; rat catechol O-methyltransferase at high pH in complex with a bisubstrate inhibitor; To be published,

Experimental method

X-RAY DIFFRACTION (1.2 Å)