5LPG

Structure of NUDT15 in complex with 6-thio-GMP

Summary for 5LPG

• Entry DOI: 10.2210/pdb5lpg/pdb
• Descriptor: Probable 8-oxo-dGTP diphosphatase NUDT15, MAGNESIUM ION, [(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-6-sulfanyl-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl dihydrogen phosphate, ... (4 entities in total)
• Functional Keywords: mth2, dna repair enzyme, cancer, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 37770.82

Authors

Masuyer, G.,Carter, M.,Rehling, D.,Stenmark, P.,Helleday, T.,Jemth, A.-S.,Valerie, N.C.K.,Homan, E.,Herr, P.,Bevc, L.,Page, B.D.G.,Hagenkort, A. (deposition date: 2016-08-12, release date: 2016-08-24, Last modification date: 2024-01-10)

• Primary citation: Valerie, N.C.,Hagenkort, A.,Page, B.D.,Masuyer, G.,Rehling, D.,Carter, M.,Bevc, L.,Herr, P.,Homan, E.,Sheppard, N.G.,Stenmark, P.,Jemth, A.S.,Helleday, T.; NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-Thioguanine.; Cancer Res., 76:5501-5511, 2016; PubMed: 27530327; DOI: 10.1158/0008-5472.CAN-16-0584

Experimental method

X-RAY DIFFRACTION (1.7 Å)