5LNZ

HSP90 WITH indazole derivative

Summary for 5LNZ

Entry DOI	10.2210/pdb5lnz/pdb
Descriptor	Heat shock protein HSP 90-alpha, ~{N}3-butyl-~{N}3,~{N}5-dimethyl-~{N}5-(4-morpholin-4-ylphenyl)-6-oxidanyl-2~{H}-indazole-3,5-dicarboxamide (3 entities in total)
Functional Keywords	chaperone
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	26179.37
Authors	Graedler, U.,Amaral, M.,Schuetz, D. (deposition date: 2016-08-08, release date: 2017-11-29, Last modification date: 2024-01-10)
Primary citation	Schuetz, D.A.,Richter, L.,Amaral, M.,Grandits, M.,Gradler, U.,Musil, D.,Buchstaller, H.P.,Eggenweiler, H.M.,Frech, M.,Ecker, G.F. Ligand Desolvation Steers On-Rate and Impacts Drug Residence Time of Heat Shock Protein 90 (Hsp90) Inhibitors. J. Med. Chem., 61:4397-4411, 2018 Cited by PubMed: 29701469 DOI: 10.1021/acs.jmedchem.8b00080 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.54 Å)

Structure validation