5LMK

Structure of phopsho-CDK2-cyclin A in complex with an ATP-competitive inhibitor

5LMK の概要

• エントリーDOI: 10.2210/pdb5lmk/pdb
• 分子名称: Cyclin-dependent kinase 2, Cyclin-A2, 4-[4-[3-bromanyl-7-(pyridin-3-ylmethylamino)pyrazolo[1,5-a]pyrimidin-5-yl]phenyl]benzamide, ... (7 entities in total)
• 機能のキーワード: cdk2; cyclin a, cell cycle, transferase, inhibitor, complex
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 128504.68

構造登録者

Echalier, A. (登録日: 2016-08-01, 公開日: 2017-01-25, 最終更新日: 2019-10-16)

• 主引用文献: Hylsova, M.,Carbain, B.,Fanfrlik, J.,Musilova, L.,Haldar, S.,Kopruluoglu, C.,Ajani, H.,Brahmkshatriya, P.S.,Jorda, R.,Krystof, V.,Hobza, P.,Echalier, A.,Paruch, K.,Lepsik, M.; Explicit treatment of active-site waters enhances quantum mechanical/implicit solvent scoring: Inhibition of CDK2 by new pyrazolo[1,5-a]pyrimidines.; Eur J Med Chem, 126:1118-1128, 2016; PubMed: 28039837; DOI: 10.1016/j.ejmech.2016.12.023

実験手法

X-RAY DIFFRACTION (2.4 Å)