5LLS

Porcine dipeptidyl peptidase IV in complex with 8-(3-aminopiperidin-1-yl)-7-[(2-bromophenyl)methyl]-1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione

5LLS の概要

• エントリーDOI: 10.2210/pdb5lls/pdb
• 分子名称: Dipeptidyl peptidase 4, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: peptidase, inhibitor, complex, hydrolase
• 由来する生物種: Sus scrofa (Pig)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 364428.55

構造登録者

Nar, H.,Blaesse, M. (登録日: 2016-07-28, 公開日: 2016-09-14, 最終更新日: 2024-01-10)

• 主引用文献: Schnapp, G.,Klein, T.,Hoevels, Y.,Bakker, R.A.,Nar, H.; Comparative Analysis of Binding Kinetics and Thermodynamics of Dipeptidyl Peptidase-4 Inhibitors and Their Relationship to Structure.; J.Med.Chem., 59:7466-7477, 2016; PubMed: 27438064; DOI: 10.1021/acs.jmedchem.6b00475

実験手法

X-RAY DIFFRACTION (2.41 Å)