5LKY

X-ray crystal structure of N-acetylneuraminic acid lyase in complex with pyruvate, with the phenylalanine at position 190 replaced with the non-canonical amino acid dihydroxypropylcysteine.

5LKY の概要

• エントリーDOI: 10.2210/pdb5lky/pdb
• 分子名称: N-acetylneuraminate lyase, DI(HYDROXYETHYL)ETHER (3 entities in total)
• 機能のキーワード: aldolase, non-canonical amino acid, tim barrel, lyase
• 由来する生物種: Staphylococcus aureus (strain NCTC 8325)
• 細胞内の位置: Cytoplasm : Q2G160
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 136746.41

構造登録者

Windle, C.L.,Trinh, C.H.,Pearson, A.R.,Nelson, A.S.,Berry, A. (登録日: 2016-07-25, 公開日: 2017-03-22, 最終更新日: 2024-01-10)

• 主引用文献: Windle, C.L.,Simmons, K.J.,Ault, J.R.,Trinh, C.H.,Nelson, A.,Pearson, A.R.,Berry, A.; Extending enzyme molecular recognition with an expanded amino acid alphabet.; Proc. Natl. Acad. Sci. U.S.A., 114:2610-2615, 2017; PubMed: 28196894; DOI: 10.1073/pnas.1616816114

実験手法

X-RAY DIFFRACTION (1.7 Å)