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5LJT

Crystal structure of human carbonic anhydrase II in complex with the 4-((1-phenyl-1H-1,2,3-triazol-4-yl)methoxy)benzenesulfonamide inhibitor

Summary for 5LJT
Entry DOI10.2210/pdb5ljt/pdb
DescriptorCarbonic anhydrase 2, ZINC ION, 4-[[4-[azanyl-bis(oxidanyl)-$l^{4}-sulfanyl]phenoxy]methyl]-1-phenyl-1,2,3-triazole, ... (5 entities in total)
Functional Keywordslyase
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm : P00918
Total number of polymer chains1
Total formula weight29560.67
Authors
Ferraroni, M.,Supuran, C. (deposition date: 2016-07-19, release date: 2017-06-21, Last modification date: 2024-01-10)
Primary citationNocentini, A.,Ferraroni, M.,Carta, F.,Ceruso, M.,Gratteri, P.,Lanzi, C.,Masini, E.,Supuran, C.T.
Benzenesulfonamides Incorporating Flexible Triazole Moieties Are Highly Effective Carbonic Anhydrase Inhibitors: Synthesis and Kinetic, Crystallographic, Computational, and Intraocular Pressure Lowering Investigations.
J. Med. Chem., 59:10692-10704, 2016
Cited by
PubMed: 27933963
DOI: 10.1021/acs.jmedchem.6b01389
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1 Å)
Structure validation

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