5LIA

Crystal structure of murine autotaxin in complex with a small molecule inhibitor

5LIA の概要

• エントリーDOI: 10.2210/pdb5lia/pdb
• 分子名称: Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, 1,2-ETHANEDIOL, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total)
• 機能のキーワード: lysophospholipase d, autotaxin, enpp2, hydrolase
• 由来する生物種: Mus musculus (Mouse)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 98955.72

構造登録者

Turnbull, A.P.,Shah, P.,Cheasty, A.,Raynham, T.,Pang, L.,Owen, P. (登録日: 2016-07-14, 公開日: 2016-11-09, 最終更新日: 2024-01-10)

• 主引用文献: Shah, P.,Cheasty, A.,Foxton, C.,Raynham, T.,Farooq, M.,Gutierrez, I.F.,Lejeune, A.,Pritchard, M.,Turnbull, A.,Pang, L.,Owen, P.,Boyd, S.,Stowell, A.,Jordan, A.,Hamilton, N.M.,Hitchin, J.R.,Stockley, M.,MacDonald, E.,Quesada, M.J.,Trivier, E.,Skeete, J.,Ovaa, H.,Moolenaar, W.H.,Ryder, H.; Discovery of potent inhibitors of the lysophospholipase autotaxin.; Bioorg. Med. Chem. Lett., 26:5403-5410, 2016; PubMed: 27780639; DOI: 10.1016/j.bmcl.2016.10.036

実験手法

X-RAY DIFFRACTION (1.92 Å)